Article
Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling.
International journal of biological sciences - 1 Jan 2021
Han Qi, Chen Huiling, Wang Likai, An Yang, Hu Xiaoxiang, Zhao Yaofeng, Zhang Hao, Zhang Ran
Abstract excerpt
Laron syndrome (LS) is an autosomal recessive genetic disease mainly caused by mutations in the human growth hormone receptor (GHR) gene. Previous studies have focused on Ghr mutant mice, but compared with LS patients, Ghr knockout (KO) mice exhibit differential lipid metabolism. To elucidate the relationship between GHR mutation and lipid metabolism, the role of GHR in lipid metabolism was examined in GHR KO...
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