Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibroblast transition to an endothelial “trans” state improves cell reprogramming efficiency

19 Nov 2021

Abstract excerpt

Abstract Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 (GMT) to assess the cardio-differentiation potential of these cells. The endothelial cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Pluripotent Stem Cells Research
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34799643
DOI: 10.1038/s41598-021-02056-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibroblast transition to an endothelial “trans” state improves cell reprogramming efficiencyPMID 34799643Read ↗

Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell LineageSemantic proximity Read ↗

Direct Cardiac ReprogrammingSemantic proximity Read ↗

Reprogramming of human fibroblasts toward a cardiac fate.Semantic proximity Read ↗

TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue EngineeringSemantic proximity Read ↗

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNASemantic proximity Read ↗

Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications.Semantic proximity Read ↗

Cardiac regeneration by direct reprogramming in this decade and beyondSemantic proximity Read ↗

Making steady progress on direct cardiac reprogramming toward clinical application.Semantic proximity Read ↗

Human fetal and adult epicardial-derived cells: a novel model to study their activationSemantic proximity Read ↗

Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regenerationSemantic proximity Read ↗

Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular DiseasesSemantic proximity Read ↗

From fibroblast cells to cardiomyocytes: direct lineage reprogrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.