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Article

Regulation of AKT Signaling in Mouse Uterus.

Endocrinology - 1 Jan 2022

Sirohi Vijay K, Medrano Theresa I, Mesa Ana M, Kannan Athilakshmi, Bagchi Indrani C, Cooke Paul S

Abstract excerpt

17β-estradiol (E2) treatment of ovariectomized adult mice stimulates the uterine PI3K-AKT signaling pathway and epithelial proliferation through estrogen receptor 1 (ESR1). However, epithelial proliferation occurs independently of E2/ESR1 signaling in neonatal uteri. Similarly, estrogen-independent uterine epithelial proliferation is seen in adulthood in mice lacking Ezh2, critical for histone methylation, and in...

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Identifiers

PMID: 34791100
DOI: 10.1210/endocr/bqab233
PMCID: PMC8667855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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