Article
Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.
Annals of the rheumatic diseases - 1 Mar 2022
Saper Vivian E, Ombrello Michael J, Tremoulet Adriana H, Montero-Martin Gonzalo, Prahalad Sampath, Canna Scott, Shimizu Chisato, Deutsch Gail, Tan Serena Y, Remmers Elaine F, Monos Dimitri, Hahn Timothy, Phadke Omkar K, Cassidy Elaine, Ferguson Ian, Mallajosyula Vamsee, Xu Jianpeng, Rosa Duque Jaime S, Chua Gilbert T, Ghosh Debopam, Szymanski Ann Marie, Rubin Danielle, Burns Jane C, Tian Lu, Fernandez-Vina Marcelo A, Mellins Elizabeth D, Hollenbach Jill A
Abstract excerpt
OBJECTIVES: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, delayed hypersensitivity reaction (DHR). We observed DRESS to inhibitors of interleukin 1 (IL-1) or IL-6 in a small group of patients with Still's disease with atypical lung disease. We sought to characterise features of patients with Still's disease with DRESS compared with drug-tolerant Still's controls. We analysed human...
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