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Article

Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15.

Cell reports - 5 Nov 2019

Ting Tabitha C, Goralski Maria, Klein Katherine, Wang Baiyun, Kim Jiwoong, Xie Yang, Nijhawan Deepak

Abstract excerpt

Indisulam and related sulfonamides recruit the splicing factor RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase, resulting in RBM39 ubiquitination and degradation. Here, we used a combination of domain mapping and random mutagenesis to identify domains or residues that are necessary for indisulam-dependent RBM39 ubiquitination. DCAF15 mutations at Q232 or D475 prevent RBM39 recruitment by indisulam. RBM39 is...

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Identifiers

PMID: 31693891
DOI: 10.1016/j.celrep.2019.09.079
PMCID: PMC7950731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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