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Article

Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study.

PloS one - 1 Jan 2021

Hayashi Koji, Noguchi-Shinohara Moeko, Sato Takehiro, Hosomichi Kazuyoshi, Kannon Takayuki, Abe Chiemi, Domoto Chiaki, Yuki-Nozaki Sohshi, Mori Ayaka, Horimoto Mai, Yokogawa Masami, Sakai Kenji, Iwasa Kazuo, Komai Kiyonobu, Ishimiya Mai, Nakamura Hiroyuki, Ishida Natsuko, Suga Yukio, Ishizaki Junko, Ishigami Akihito, Tajima Atsushi, Yamada Masahito

Abstract excerpt

Apolipoprotein E E4 (APOE4) is a risk factor for cognitive decline. A high blood vitamin C (VC) level reduces APOE4-associated risk of developing cognitive decline in women. In the present study, we aimed to examine the effects of functional variants of VC transporter genes expressed in the brain (SLC2A1, SLC2A3, and SLC23A2) on APOE4-associated risk of developing cognitive decline. This case-control study...

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Identifiers

PMID: 34780525
DOI: 10.1371/journal.pone.0259663
PMCID: PMC8592483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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