A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort.

doi:10.3233/JAD-150862

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Article

A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort.

Journal of Alzheimer's disease : JAD - 15 Jun 2016

Skrobot Olivia Anna, McKnight Amy Jayne, Passmore Peter Anthony, Seripa Davide, Mecocci Patrizia, Panza Francesco, Kalaria Rajesh, Wilcock Gordon, Munafò Marcus, Erkinjuntti Timo, Karhunen Pekka, Pessi Tanja, Martiskainen Mika, Love Seth, Kehoe Patrick Gavin

Abstract excerpt

Vascular cognitive impairment (VCI), including its severe form, vascular dementia (VaD), is the second most common form of dementia. The genetic etiology of sporadic VCI remains largely unknown. We previously conducted a systematic review and meta-analysis of all published genetic association studies of sporadic VCI prior to 6 July 2012, which demonstrated that APOE (ɛ4, ɛ2) and MTHFR (rs1801133) variants were...

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PMID: 27314523
DOI: 10.3233/JAD-150862

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APOE
MTHFR

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