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Development and validation of a reporter gene assay to determine the bioactivity of anti-CTLA-4 monoclonal antibodies.

International immunopharmacology - 1 Dec 2021

Liu Chunyu, Yu Chuanfei, Yang Yalan, Cui Yongfei, Zhang Feng, Wang Lan, Wang Junzhi

Abstract excerpt

CTLA-4 is an important immune checkpoint for the regulation of T cell activation, and anti-CTLA-4 monoclonal antibodies (mAbs) are being developed as mono- or combination therapy for various tumors with reliable clinical efficacy. Ipilimumab is the first approved inhibitor of immune checkpoint, and many other anti-CTLA-4 mAbs, including ipilimumab biosimilars, are in different stages of clinical trials. However,...

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PMID: 34773758
DOI: 10.1016/j.intimp.2021.108277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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