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Antitumor effect of plant-produced anti-CTLA-4 monoclonal antibody in a murine model of colon cancer

29 Aug 2023

Abstract excerpt

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is an immune checkpoint regulator exclusively expressed on T cells that obstructs the cell’s effector functions. Ipilimumab (Yervoy®), a CTLA-4 blocking antibody, emerged as a notable breakthrough in modern cancer treatment, showing upfront clinical benefits in multiple carcinomas. However, the exhilarating cost of checkpoint blockade therapy is discouraging...

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PMID: 37711295
DOI: 10.3389/fpls.2023.1149455

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