Article
Integrated analysis of genotype and phenotype reveals clonal evolution and cytogenetically driven disruption of myeloid cell maturation in myelodysplastic syndromes.
Cytometry. Part B, Clinical cytometry - 1 Mar 2023
Cutler Jevon A, Pugsley Haley R, Bennington Richard, Fritschle Wayne, Hartmann Luise, Zaidi Nigar, Menssen Andrew J, Singleton Timothy P, Xu Dongbin, Loken Michael R, Wells Denise A, Brodersen Lisa Eidenschink, Zehentner Barbara K
Abstract excerpt
BACKGROUND: Myelodysplastic syndromes (MDS) are a heterogenous collection of clonal bone marrow diseases characterized by cytopenias, abnormal karyotypes, molecular abnormalities, and dysplasia by flow cytometry and/or morphology. The progression of MDS to severe cytopenias and/or overt leukemia is associated with the accumulation of additional cytogenetic abnormalities, suggesting clonal evolution. The impact of...
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