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Article

The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes.

Nature reviews. Cancer - 1 Dec 2012

Raza Azra, Galili Naomi

Abstract excerpt

Myelodysplastic syndromes (MDS) are malignant clonal disorders of haematopoietic stem cells and their microenvironment, affecting older individuals (median age ∼70 years). Unique features that are associated with MDS - but which are not necessarily present in every patient with MDS - include excessive apoptosis in maturing clonal cells, a pro-inflammatory bone marrow microenvironment, specific chromosomal...

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PMID: 23175121
DOI: 10.1038/nrc3321

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