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MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness

12 Nov 2021

Abstract excerpt

Deregulated mitochondrial energetics is a metabolic hallmark of cancer cells. However, the causative mechanism of the bioenergetic deregulation is not clear. In this study, we show that somatic copy number alteration (SCNA) of mitoribosomal protein (MRP) genes is a key mechanism of bioenergetic deregulation in hepatocellular carcinoma (HCC). Association analysis between the genomic and transcriptomic profiles of...

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PMID: 34772924
DOI: 10.1038/s41419-021-04370-8

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