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Article

Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.

Acta neuropathologica communications - 12 Nov 2021

Sano Kazunori, Iwasaki Yasushi, Yamashita Yuta, Irie Keiichi, Hosokawa Masato, Satoh Katsuya, Mishima Kenichi

Abstract excerpt

Serine 129 (S129) phosphorylation of α-synuclein (αSyn) is a central feature of Lewy body (LB) disease pathology. Although the neighboring tyrosine residues Y125, Y133, and Y136 are also phosphorylation sites, little is known regarding potential roles of phosphorylation cross-talk between these sites and its involvement in the pathogenesis of LB disease. Here, we found that αSyn aggregates are predominantly...

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PMID: 34772466
DOI: 10.1186/s40478-021-01281-9
PMCID: PMC8590312

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