Article
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
FEBS letters - 2 Oct 2007
Ishii Aasami, Nonaka Takashi, Taniguchi Sayuri, Saito Taro, Arai Tetsuaki, Mann David, Iwatsubo Takeshi, Hisanaga Shin-Ichi, Goedert Michel, Hasegawa Masato
Abstract excerpt
In Lewy body diseases and multiple system atrophy, alpha-synuclein is hyperphosphorylated at Ser129, suggesting a role in pathogenesis. Here, we report purification of the protein kinase in rat brain that phosphorylates Ser129 and its identification as casein kinase-2 (CK2). We show that most of the activity can be inhibited by heparin, an inhibitor of CK2. Phosphorylated Ser129 was detected in primary cultured...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.