Article
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
FEBS letters - 2 Oct 2007
Ishii Aasami, Nonaka Takashi, Taniguchi Sayuri, Saito Taro, Arai Tetsuaki, Mann David, Iwatsubo Takeshi, Hisanaga Shin-Ichi, Goedert Michel, Hasegawa Masato
Abstract excerpt
In Lewy body diseases and multiple system atrophy, alpha-synuclein is hyperphosphorylated at Ser129, suggesting a role in pathogenesis. Here, we report purification of the protein kinase in rat brain that phosphorylates Ser129 and its identification as casein kinase-2 (CK2). We show that most of...
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