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Article

A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent Klebsiella pneumoniae.

Microbiology spectrum - 2 Dec 2025

Yin Ming, Cao Li, Fu Yu, Lu Yanjun, Yan Yi, Qian Lvxin, Xiang Li, Zhou Tiejun, Chen Huan, Li Ying, Zhang Luhua

Abstract excerpt

Bacteriophage (phage) therapy is a promising alternative antibacterial approach for treating infectious diseases by hvKp. However, there has been a lack of studies on the host recognition and infection initiation of hvKp phages. In this work, we found that both capsular polysaccharide (CPS) and lipopolysaccharide (LPS) of strain SCNJ1 are essential for phage infection, and mutations in genes associated with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41212188
DOI: 10.1128/spectrum.02171-25
PMCID: PMC12671077

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