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Article

Systematic profiling of temperature- and retinal-sensitive rhodopsin variants by deep mutational scanning.

The Journal of biological chemistry - 1 Dec 2021

McKee Andrew G, Kuntz Charles P, Ortega Joseph T, Woods Hope, Most Victoria, Roushar Francis J, Meiler Jens, Jastrzebska Beata, Schlebach Jonathan P

Abstract excerpt

Membrane protein variants with diminished conformational stability often exhibit enhanced cellular expression at reduced growth temperatures. The expression of "temperature-sensitive" variants is also typically sensitive to corrector molecules that bind and stabilize the native conformation. There are many examples of temperature-sensitive rhodopsin variants, the misfolding of which is associated with the...

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Identifiers

PMID: 34756884
DOI: 10.1016/j.jbc.2021.101359
PMCID: PMC8649220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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