Article
Hierarchical genotype networks and incipient ecological speciation in Q[Formula: see text] phage quasispecies.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2026
Seoane Luís F, Secaira-Morocho Henry, Somovilla Pilar, Lázaro Ester, Manrubia Susanna
Abstract excerpt
Understanding how viral mutant spectra organize and explore genotype space is essential for elucidating the mechanisms that drive molecular evolution. Here, we use deep-sequencing data of an amplicon in the A2 protein of the RNA bacteriophage Q[Formula: see text] to reconstruct genotype networks comprising tens of thousands of haplotypes. The study of populations evolved under different temperature regimes...
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