Article
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants.
Journal of virology - 14 Sept 2022
Su Chao, He Juanhua, Han Pengcheng, Bai Bin, Li Dedong, Cao Jian, Tian Mingxiong, Hu Yu, Zheng Anqi, Niu Sheng, Chen Qian, Rong Xiaoyu, Zhang Yanfang, Li Weiwei, Qi Jianxun, Zhao Xin, Yang Mengsu, Wang Qihui, Gao George Fu
Abstract excerpt
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted between humans and minks, and some mutations in the spike (S) protein, especially in the receptor-binding domain (RBD), have been identified in mink-derived viruses. Here, we examined binding of the mink angiotensin-converting enzyme 2 (ACE2) receptor to mink-derived and important human-originating variants, and we demonstrated that most...
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