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Article

Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers

7 Nov 2021

Abstract excerpt

BACKGROUND: Adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells combined with checkpoint inhibition may prevent T cell exhaustion and improve clinical outcomes. However, the approach is limited by cumulative costs and toxicities. METHODS: To overcome this drawback, we created a CAR-T (RB-340-1) that unites in one product the two modalities: a CRISPR interference-(CRISPRi) circuit prevents...

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PMID: 34743703
DOI: 10.1186/s12967-021-03132-6

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