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Multispecific targeting of glioblastoma with tumor microenvironment-responsive multifunctional engineered NK cells

5 Nov 2021

Abstract excerpt

Tumor antigen heterogeneity, a severely immunosuppressive tumor microenvironment (TME) and lymphopenia resulting in inadequate immune intratumoral trafficking, have rendered glioblastoma (GBM) highly resistant to therapy. To address these obstacles, here we describe a unique, sophisticated combinatorial platform for GBM: a cooperative multifunctional immunotherapy based on genetically engineered human natural...

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PMID: 34740973
DOI: 10.1073/pnas.2107507118

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