Article
No evidence of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16(INK4a) status.
Human pathology - 1 Nov 2014
Prigge Elena-Sophie, Urban Katharina, Stiegler Sandrine, Müller Meike, Kloor Matthias, Mai Sabine, Ottstadt Martine, Lohr Frank, Wenz Frederik, Wagner Steffen, Wittekindt Claus, Klussmann Jens Peter, Hampl Monika, von Knebel Doeberitz Magnus, Reuschenbach Miriam
Abstract excerpt
Carcinogenesis of squamous cell carcinomas (SCCs) in the anogenital tract and head and neck region is heterogeneous. A substantial proportion of SCC in the vulva, anus, and head and neck follows a human papillomavirus (HPV)-induced carcinogenic pathway. However, the molecular pathways of carcinogenesis in the HPV-independent lesions are not completely understood. We hypothesized that oncogenic Kirsten rat sarcoma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.