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Article

The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network.

Scientific reports - 3 Nov 2021

Selenius Jannica S, Silveira Patricia P, Salonen Minna, Kautiainen Hannu, von Bonsdorff Mikaela, Kajantie Eero, Lahti Jari, Eriksson Johan G, Wasenius Niko S

Abstract excerpt

To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components...

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Identifiers

PMID: 34732766
DOI: 10.1038/s41598-021-00631-w
PMCID: PMC8566480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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