The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.

doi:10.1016/j.bbagen.2021.130048

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Article

The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.

Biochimica et biophysica acta. General subjects - 1 Feb 2022

Kumagai Hiroshi, Natsume Toshiharu, Kim Su-Jeong, Tobina Takuro, Miyamoto-Mikami Eri, Shiose Keisuke, Ichinoseki-Sekine Noriko, Kakigi Ryo, Tsuzuki Takamasa, Miller Brendan, Yen Kelvin, Murakami Haruka, Miyachi Motohiko, Zempo Hirofumi, Dobashi Shohei, Machida Shuichi, Kobayashi Hiroyuki, Naito Hisashi, Cohen Pinchas, Fuku Noriyuki

Abstract excerpt

Human skeletal muscle fiber is heterogenous due to its diversity of slow- and fast-twitch fibers. In human, slow-twitched fiber gene expression is correlated to MOTS-c, a mitochondria-derived peptide that has been characterized as an exercise mimetic. Within the MOTS-c open reading frame, there is an East Asian-specific m.1382A>C polymorphism (rs111033358) that changes the 14th amino acid of MOTS-c (i.e., K14Q),...

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PMID: 34728329
DOI: 10.1016/j.bbagen.2021.130048
PMCID: PMC8741734

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