A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.

doi:10.18632/aging.202529

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A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.

Aging - 19 Jan 2021

Zempo Hirofumi, Kim Su-Jeong, Fuku Noriyuki, Nishida Yuichiro, Higaki Yasuki, Wan Junxiang, Yen Kelvin, Miller Brendan, Vicinanza Roberto, Miyamoto-Mikami Eri, Kumagai Hiroshi, Naito Hisashi, Xiao Jialin, Mehta Hemal H, Lee Changhan, Hara Megumi, Patel Yesha M, Setiawan Veronica W, Moore Timothy M, Hevener Andrea L, Sutoh Yoichi, Shimizu Atsushi, Kojima Kaname, Kinoshita Kengo, Arai Yasumichi, Hirose Nobuyoshi, Maeda Seiji, Tanaka Keitaro, Cohen Pinchas

Abstract excerpt

Type 2 Diabetes (T2D) is an emerging public health problem in Asia. Although ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the functional effects of the mtDNA polymorphisms and the therapeutic potential of mitochondrial-derived peptides at the mtDNA polymorphisms are underexplored. Here, we showed an Asian-specific mitochondrial DNA variation m.1382A>C (rs111033358) leads to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33468709
DOI: 10.18632/aging.202529
PMCID: PMC7880332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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