Article
A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
Communications biology - 20 May 2024
Ito Shuji, Takuwa Hiroshi, Kakehi Saori, Someya Yuki, Kaga Hideyoshi, Kumahashi Nobuyuki, Kuwata Suguru, Wakatsuki Takuya, Kadowaki Masaru, Yamamoto Soichiro, Abe Takafumi, Takeda Miwako, Ishikawa Yuki, Liu Xiaoxi, Otomo Nao, Suetsugu Hiroyuki, Koike Yoshinao, Hikino Keiko, Tomizuka Kohei, Momozawa Yukihide, Ozaki Kouichi, Isomura Minoru, Nabika Toru, Kaneko Haruka, Ishijima Muneaki, Kawamori Ryuzo, Watada Hirotaka, Tamura Yoshifumi, Uchio Yuji, Ikegawa Shiro, Terao Chikashi
Abstract excerpt
Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an...
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