Article
Thoughts on aneuploidy.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2010
Torres E M, Williams B R, Tang Y-C, Amon A
Abstract excerpt
Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level. Furthermore, we find that aneuploid cells exhibit phenotypes consistent with...
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