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Article

New techniques to understand chromosome dosage: mouse models of aneuploidy.

Human molecular genetics - 15 Oct 2006

Tybulewicz Victor L J, Fisher Elizabeth M C

Abstract excerpt

Aberrations in human chromosome copy number and structure are common and extremely deleterious. Their downstream effects on phenotype are caused by aberrant dosage of sequences in the affected regions. However, we know little about why the abnormal gene copy number causes disease or why specific features result from deficits in specific chromosomes. Mice are the organism of choice to help us try to tease apart...

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Identifiers

PMID: 16987872
DOI: 10.1093/hmg/ddl179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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