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Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells.

Chemico-biological interactions - 5 Jan 2022

Mi Chunliu, Cao Xiangxiang, Ma Kai, Wei Mian, Xu Wenjing, Lin Yan, Zhang Jihong, Wang Tian-Yun

Abstract excerpt

Colon cancer patients with mutant KRAS are resistant to cetuximab, an antibody directed against the epidermal growth factor receptor. New treatment options are needed to improve survival in patients with KRAS mutated colorectal cancer. Digitoxin is a cardiotonic drug, which has been demonstrated to exhibit anticancer effects in a number of cancers. However, the anticancer mechanisms of digitoxin in KRAS mutant...

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Identifiers

PMID: 34717917
DOI: 10.1016/j.cbi.2021.109729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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