Article
Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation.
Molecules (Basel, Switzerland) - 18 Mar 2016
Zhang Yi-Ze, Chen Xi, Fan Xing-Xing, He Jian-Xing, Huang Jun, Xiao Da-Kai, Zhou Yan-Ling, Zheng Sen-You, Xu Jia-Hui, Yao Xiao-Jun, Liu Liang, Leung Elaine Lai-Han
Abstract excerpt
Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC. In the clinic, molecular-targeting with Gefitinib as a tyrosine kinase inhibitor (TKI) for EGFR downstream signaling is initially effective. However, drug resistance frequently happens due to additional mutation on EGFR, such as substitution...
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