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Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro.

Journal of microbiology and biotechnology - 13 Mar 2026

Kwon Mikyoung, Jung Hye Jin

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, largely due to metastasis and therapeutic resistance. Beauvericin, a cyclohexadepsipeptide mycotoxin produced by Beauveria and Cordyceps species, has demonstrated anticancer activity in multiple malignancies; however, its mechanistic effects in CRC have not been fully defined. In this study, we investigated the cellular and molecular...

Topics

Humans
Depsipeptides
Apoptosis
Colorectal Neoplasms
Epithelial-Mesenchymal Transition
Mitochondria
Signal Transduction
Cell Line, Tumor
Cell Proliferation
Cell Survival
Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HCT116 Cells

Cell Movement

Neovascularization, Pathologic

Cell Cycle Checkpoints

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41834564
DOI: 10.4014/jmb.2511.11035
PMCID: PMC13003326

Genes

JAK2
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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