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Article

Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2021

Harley Carol A, Bernardo-Seisdedos Ganeko, Stevens-Sostre Whitney A, Jones David K, Azevedo Maria M, Sampaio Paula, Lorga-Gomes Marta, Trudeau Matthew C, Millet Oscar, Robertson Gail A, Morais-Cabral João H

Abstract excerpt

The human ERG (hERG) K+ channel has a crucial function in cardiac repolarization, and mutations or channel block can give rise to long QT syndrome and catastrophic ventricular arrhythmias. The cytosolic assembly formed by the Per-Arnt-Sim (PAS) and cyclic nucleotide binding homology (CNBh) domains is the defining structural feature of hERG and related KCNH channels. However, the molecular role of these two...

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Identifiers

PMID: 34716268
DOI: 10.1073/pnas.2108796118
PMCID: PMC8612226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating.PMID 34716268Read ↗

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