Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis.

doi:10.1182/blood-2007-07-099564

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Article

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis.

Blood - 1 Feb 2008

Murray Fiona, Darzentas Nikos, Hadzidimitriou Anastasia, Tobin Gerard, Boudjogra Myriam, Scielzo Cristina, Laoutaris Nikolaos, Karlsson Karin, Baran-Marzsak Fanny, Tsaftaris Athanasios, Moreno Carol, Anagnostopoulos Achilles, Caligaris-Cappio Federico, Vaur Dominique, Ouzounis Christos, Belessi Chrysoula, Ghia Paolo, Davi Fred, Rosenquist Richard, Stamatopoulos Kostas

Abstract excerpt

Somatic hypermutation (SHM) features in a series of 1967 immunoglobulin heavy chain gene (IGH) rearrangements obtained from patients with chronic lymphocytic leukemia (CLL) were examined and compared with IGH sequences from non-CLL B cells available in public databases. SHM analysis was performed for all 1290 CLL sequences in this cohort with less than 100% identity to germ line. At the cohort level, SHM patterns...

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PMID: 17959859
DOI: 10.1182/blood-2007-07-099564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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