Article
Therapeutic inhibition of isocitrate dehydrogenase mutations in glioma and cholangiocarcinoma: new insights and promises-a narrative review.
Chinese clinical oncology - 1 Oct 2024
Internò Valeria, Melaccio Assunta, Vitale Pasquale, Spedaliere Roberta, Buonfantino Massimo, Messina Raffaella, Lippolis Anna Laura, Signorelli Francesco, Addeo Raffaele, Giuliani Francesco
Abstract excerpt
BACKGROUND AND OBJECTIVE: The identification of mutation hot spots in the isocitrate dehydrogenase (IDH) genes is one of the most important cancer genome-wide sequencing discoveries with relevant impact in the treatment of some orphan tumors. These genes were mostly found mutated in lower-grade gliomas (LGGs), acute myeloid leukaemia (AML), myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs)...
Topics
Join the communities discussing this publication.