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Article

Chronic pain and delinquency partially explain the effect of the DRD4 gene polymorphism on adult substance use.

The American journal of drug and alcohol abuse - 4 Mar 2022

Yang James J, Wang Zhi, Trucco Elisa M, Buu Anne, Lin Hsien-Chang

Abstract excerpt

Background: The dopamine receptor D4 [DRD4] has been reported to be associated with substance use. Yet, the roles that health conditions and behaviors may play in such association are understudied.Objective: This longitudinal study investigated the potential mediation effects of chronic pain and delinquency in adolescence on the association between the DRD4 2-repeat allele and substance use in adulthood. Sex,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34710332
DOI: 10.1080/00952990.2021.1977311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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