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Article

The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects.

Addiction biology - 1 Apr 2009

Ray Lara A, Bryan Angela, Mackillop James, McGeary John, Hesterberg Kirstin, Hutchison Kent E

Abstract excerpt

The present study sought to integrate convergent lines of research on the associations among the dopamine D(4) receptor (DRD4) gene, novelty seeking and drinking behaviors with the overall goal of elucidating genetic influences on problematic drinking in young adulthood. Specifically, this study tested a model in which novelty seeking mediated the relationship between DRD4 variable number of tandem repeats (VNTR)...

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Source

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Identifiers

PMID: 18715282
DOI: 10.1111/j.1369-1600.2008.00120.x
PMCID: PMC3151559

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects.PMID 18715282Read ↗

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The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sampleSemantic proximity Read ↗

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