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Translational and clinical comparison of whole genome and transcriptome to panel sequencing in precision oncology

10 Jan 2025

Abstract excerpt

Precision oncology offers new cancer treatment options, yet sequencing methods vary in type and scope. In this study, we compared whole-exome/whole-genome (WES/WGS) and transcriptome sequencing (TS) with broad panel sequencing by resequencing the same tumor DNA and RNA as well as normal tissue DNA for germline assessment, from 20 patients with rare or advanced tumors, who were originally sequenced by WES/WGS ± TS...

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Cancer Genomics and Diagnostics
Genetic factors in colorectal cancer
Lung Cancer Treatments and Mutations

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39794422
DOI: 10.1038/s41698-024-00788-3

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