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Article

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.

Nature communications - 26 Oct 2021

Kimishima Yusuke, Misaka Tomofumi, Yokokawa Tetsuro, Wada Kento, Ueda Koki, Sugimoto Koichi, Minakawa Keiji, Nakazato Kazuhiko, Ishida Takafumi, Oshima Motohiko, Koide Shuhei, Shide Kotaro, Shimoda Kazuya, Iwama Atsushi, Ikeda Kazuhiko, Takeishi Yasuchika

Abstract excerpt

Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by pulmonary arterial remodeling. Clonal somatic mutations including JAK2V617F, the most frequent driver mutation among myeloproliferative neoplasms, have recently been identified in healthy individuals without hematological disorders. Here, we reveal that clonal hematopoiesis with JAK2V617F exacerbates PH and pulmonary arterial...

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Source

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Identifiers

PMID: 34702814
DOI: 10.1038/s41467-021-26435-0
PMCID: PMC8548396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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