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Article

Bone Marrow–derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension

9 Dec 2015

Abstract excerpt

RATIONALE: Pulmonary arterial hypertension (PAH) is a progressive lung disease of the pulmonary microvasculature. Studies suggest that bone marrow (BM)-derived circulating cells may play an important role in its pathogenesis. OBJECTIVES: We used a genetic model of PAH, the Bmpr2 mutant mouse, to study the role of BM-derived circulating cells in its pathogenesis. METHODS: Recipient mice, either Bmpr2(R899X) mutant...

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PMID: 26651104
DOI: 10.1164/rccm.201502-0407oc

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