Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child.

doi:10.1073/pnas.2114390118

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Article

Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2021

Lévy Romain, Zhang Peng, Bastard Paul, Dorgham Karim, Melki Isabelle, Hadchouel Alice, Hartoularos George C, Neven Bénédicte, Castelle Martin, Roy Charlotte, Toin Tom, Berteloot Laureline, Bizien Lucy, Abid Hanène, Burgard Marianne, Houhou-Fidouh Nadhira, Rozenberg Flore, Jouanguy Emmanuelle, Ye Chun Jimmie, Gorochov Guy, Zhang Qian, Casanova Jean-Laurent

Abstract excerpt

We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3-dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. She was viremic on day 2 and received casirivimab and imdevimab. Her clinical manifestations and viremia disappeared on days 3...

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Identifiers

PMID: 34702736
DOI: 10.1073/pnas.2114390118
PMCID: PMC8609338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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