Article
Adaptation and genomic erosion in fragmented Pseudomonas aeruginosa populations in the sinuses of people with cystic fibrosis.
Cell reports - 19 Oct 2021
Armbruster Catherine R, Marshall Christopher W, Garber Arkadiy I, Melvin Jeffrey A, Zemke Anna C, Moore John, Zamora Paula F, Li Kelvin, Fritz Ian L, Manko Christopher D, Weaver Madison L, Gaston Jordan R, Morris Alison, Methé Barbara, DePas William H, Lee Stella E, Cooper Vaughn S, Bomberger Jennifer M
Abstract excerpt
Pseudomonas aeruginosa notoriously adapts to the airways of people with cystic fibrosis (CF), yet how infection-site biogeography and associated evolutionary processes vary as lifelong infections progress remains unclear. Here we test the hypothesis that early adaptations promoting aggregation influence evolutionary-genetic trajectories by examining longitudinal P. aeruginosa from the sinuses of six adults with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.