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Defining the Prion Type of Fatal Familial Insomnia

7 Oct 2021

Abstract excerpt

Fatal familial insomnia (FFI) belongs to the genetic human transmissible spongiform encephalopathies (TSE), such as genetic Creutzfeldt-Jakob disease (CJD) or Gerstmann-Straeussler-Scheinker syndrome (GSS). Here, we analyzed the properties of the pathological prion protein in six FFI cases by Western blot analysis, a protein aggregate stability assay, and aggregate deposition characteristics visualized with the...

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PMID: 34684242
DOI: 10.3390/pathogens10101293

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