Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia.

International journal of molecular medicine - 1 Jan 2013

Xie Wu-Ling, Shi Qi, Xia Sheng-Li, Zhang Bao-Yun, Gong Han-Shi, Wang Shao-Bin, Xu Yin, Guo Yan, Tian Chan, Zhang Jin, Xu Bian-Li, Liu Yong, Dong Xiao-Ping

Abstract excerpt

Fatal familial insomnia (FFI) is an autosomal dominant prion disease clinically characterized by rapidly progressive insomnia, prominent autonomic alterations and behavioral disturbance. The D178N mutation of the prion protein gene (PRNP) on chromosome 20 in conjunction with methionine at codon 129 is a molecular feature. Although the neuropathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 20
Share to Creutzfeldt-Jakob Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endopeptidase K

Share to Gyrus Cinguli

Share to Phosphopyruvate Hydratase

Share to Prion Proteins

Share to Specimen Handling

Share to Thalamus

Source

Identifiers

PMID: 23175354
DOI: 10.3892/ijmm.2012.1194

Genes

GFAP
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia.PMID 23175354Read ↗

Fatal familial insomnia and sporadic fatal insomnia.Semantic proximity Read ↗

Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.Semantic proximity Read ↗

[The spectrum of prion pathology broadens: fatal familial insomnia].Semantic proximity Read ↗

Clinical, histopathological and genetic studies in a family with fatal familial insomnia.Semantic proximity Read ↗

Fatal familial insomniaSemantic proximity Read ↗

A subtype of sporadic prion disease mimicking fatal familial insomnia.Semantic proximity Read ↗

A sleep that never comes: Prions and their role in fatal familial insomnia - a literature review.Semantic proximity Read ↗

Sporadic Fatal Insomnia in Europe: Phenotypic Features and Diagnostic Challenges.Semantic proximity Read ↗

Clinical, histopathological and genetic studies in a case of fatal familial insomnia with review of the literature.Semantic proximity Read ↗

Familial fatal insomnia with atypical clinical features in a patient with D178N mutation and homozygosity for Met at codon 129 of the prion protein gene.Semantic proximity Read ↗

Fatal familial insomnia with a mutation at codon 178 of the prion protein gene: first report from Japan.Semantic proximity Read ↗

Fatal familial insomnia with an unusual prion protein deposition pattern: an autopsy report with an experimental transmission study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.