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Article

Pathway-based biomarker identification with crosstalk analysis for robust prognosis prediction in hepatocellular carcinoma

14 May 2019

Abstract excerpt

BACKGROUND: Although many prognostic single-gene (SG) lists have been identified in cancer research, application of these features is hampered due to poor robustness and performance on independent datasets. Pathway-based approaches have thus emerged which embed biological knowledge to yield reproducible features. METHODS: Pathifier estimates pathways deregulation score (PDS) to represent the extent of pathway...

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PMID: 31101593
DOI: 10.1016/j.ebiom.2019.05.010

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