Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis

20 Oct 2021

Abstract excerpt

Abstract High-risk human papillomaviruses (HPV), exemplified by HPV16/18, are causally linked to human cancers of the anogenital tract, skin, and upper aerodigestive tract. Previously, we identified Ecdysoneless (ECD) protein, the human homolog of the Drosophila ecdysoneless gene, as a novel HPV16 E6–interacting protein. Here, we show that ECD, through its C-terminal region, selectively binds to high-risk but not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cervical Cancer and HPV Research
Share to Invertebrate Immune Response Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34670863
DOI: 10.1158/1541-7786.mcr-21-0567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical OncogenesisPMID 34670863Read ↗

A novel RNA-binding activity of ECD contributes to U5 snRNP stability and pre-mRNA splicingSemantic proximity Read ↗

Digital RNA Sequencing of Human Epidermal Keratinocytes Carrying Human Papillomavirus Type 16 E7Semantic proximity Read ↗

Transcriptomic Analysis of HPV-Positive Oesophageal Tissue Reveals Upregulation of Genes Linked to Cell Cycle and DNA ReplicationSemantic proximity Read ↗

E6AP is important for HPV E6’s role in regulating epithelial homeostasis and its loss impairs keratinocyte commitment to differentiationSemantic proximity Read ↗

Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose MetabolismSemantic proximity Read ↗

NCoR1 Mediates Papillomavirus E8^E2C Transcriptional RepressionSemantic proximity Read ↗

The Role of Long Noncoding RNAs in Human Papillomavirus-associated PathogenesisSemantic proximity Read ↗

Transcriptome Analysis of Cervical Cancer Exosomes and Detection of HPVE6*I Transcripts in Exosomal RNASemantic proximity Read ↗

A DLEU2/E2F1 regulatory axis promotes migration and invasion phenotypes in cervical squamous cell carcinoma.Semantic proximity Read ↗

Post-Transcriptional Gene Regulation by HPV 16E6 and Its Host Protein PartnersSemantic proximity Read ↗

Differentiation-independent Activation of HPV Genome Replication by the lncRNA DINOSemantic proximity Read ↗

KNTC1, regulated by HPV E7, inhibits cervical carcinogenesis partially through Smad2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.