Article
Protocol to test the efficacy and safety of frequent applications of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomised prospective study.
BMJ open - 19 Oct 2021
Ueda Kaori, Kurimoto Takuji, Takano Fumio, Murai Yusuke, Mori Sotaro, Sakamoto Mari, Nagai Takayuki, Yamada-Nakanishi Yuko, Nakamura Makoto
Abstract excerpt
INTRODUCTION: Leber hereditary optic neuropathy (LHON) is an acute or subacute inherited optic neuropathy caused by mitochondrial mutations. More than 90% of patients with LHON have one of three point mutations (ie, G3460A, G11778A and T14484C). We previously reported that a 12-week session of skin electrical stimulation (SES) with a 2-week interval significantly improved visual acuity and field tests 1 week...
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