Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy.

EBioMedicine - 1 Aug 2016

Yang Shuo, Ma Si-Qi, Wan Xing, He Heng, Pei Han, Zhao Min-Jian, Chen Chen, Wang Dao-Wen, Dong Xiao-Yan, Yuan Jia-Jia, Li Bin

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a disease that leads to blindness. Gene therapy has been investigated with some success, and could lead to important advancements in treating LHON. This was a prospective, open-label trial involving 9 LHON patients at Tongji Hospital, Wuhan, China, from August 2011 to December 2015. The purpose of this study was to evaluate the long-term outcomes of gene therapy for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Evoked Potentials, Visual

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to NADH Dehydrogenase

Share to Optic Atrophy, Hereditary, Leber

Share to Tomography, Optical Coherence

Share to Visual Acuity

Share to Visual Fields

Source

Open in PubMed Open full text

Identifiers

PMID: 27426279
DOI: 10.1016/j.ebiom.2016.07.002
PMCID: PMC5006665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy.PMID 27426279Read ↗

Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy.Semantic proximity Read ↗

The Progress of Gene Therapy for Leber's Optic Hereditary Neuropathy.Semantic proximity Read ↗

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset.Semantic proximity Read ↗

Long-Term Follow-Up After Unilateral Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy: The RESTORE Study.Semantic proximity Read ↗

[Clinical research progress of gene therapy for Leber hereditary optic neuropathy].Semantic proximity Read ↗

Safety of rAAV2/2-ND4 Gene Therapy for Leber Hereditary Optic NeuropathySemantic proximity Read ↗

Efficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.Semantic proximity Read ↗

Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results.Semantic proximity Read ↗

Safety of Intravitreal Gene Therapy for Treatment of Subjects with Leber Hereditary Optic Neuropathy due to Mutations in the Mitochondrial ND4 Gene: The REVEAL Study.Semantic proximity Read ↗

Efficacy and Safety of Intravitreal rAAV2-ND4 Therapy for Leber’s Hereditary Optic NeuropathySemantic proximity Read ↗

Seven-Year Follow-up of Gene Therapy for Leber's Hereditary Optic Neuropathy.Semantic proximity Read ↗

[Clinical practice guidelines for Leber's hereditary optic neuropathy].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.