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Article

Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice.

Journal of pharmacological sciences - 1 Dec 2021

Li Xiaofei, Zhang Daogong, Xu Lei, Liu Wenwen, Zhang Na, Strauss Jerome F, Zhang Zhibing, Wang Haibo

Abstract excerpt

Spag6 encodes an axoneme central apparatus protein that is required for normal flagellar and cilia motility. Recent findings suggest that Spag6 plays a role in hearing and planar cell polarity (PCP) in the cochlea of the inner ear. However, a role for Spag6 in the vestibule has not yet been explored. In the present study, the function of Spag6 in the vestibule of the inner ear was examined using Spag6-deficient...

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Identifiers

PMID: 34663514
DOI: 10.1016/j.jphs.2021.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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