Article
Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).
PloS one - 1 Jan 2015
Simonov Alexandr N, Holien Jessica K, Yeung Joyee Chun In, Nguyen Ann D, Corbin C Jo, Zheng Jie, Kuznetsov Vladimir L, Auchus Richard J, Conley Alan J, Bond Alan M, Parker Michael W, Rodgers Raymond J, Martin Lisandra L
Abstract excerpt
Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achieved remains unknown. Here, comprehensive in silico, in vivo and in vitro analyses were undertaken. Fluorescence...
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