Article
Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical Determinants in Patients with MDS.
Blood cancer discovery - 1 May 2021
Brück Oscar E, Lallukka-Brück Susanna E, Hohtari Helena R, Ianevski Aleksandr, Ebeling Freja T, Kovanen Panu E, Kytölä Soili I, Aittokallio Tero A, Ramos Pedro M, Porkka Kimmo V, Mustjoki Satu M
Abstract excerpt
In myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN), bone marrow (BM) histopathology is assessed to identify dysplastic cellular morphology, cellularity, and blast excess. Yet, other morphologic findings may elude the human eye. We used convolutional neural networks to extract morphologic features from 236 MDS, 87 MDS/MPN, and 11 control BM biopsies. These features predicted genetic and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.