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Article

Understanding mutation hotspots for the SARS-CoV-2 spike protein using Shannon Entropy and K-means clustering.

Computers in biology and medicine - 1 Nov 2021

Mullick Baishali, Magar Rishikesh, Jhunjhunwala Aastha, Barati Farimani Amir

Abstract excerpt

The SARS-CoV-2 virus like many other viruses has transformed in a continual manner to give rise to new variants by means of mutations commonly through substitutions and indels. These mutations in some cases can give the virus a survival advantage making the mutants dangerous. In general, laboratory investigation must be carried to determine whether the new variants have any characteristics that can make them more...

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Identifiers

PMID: 34655896
DOI: 10.1016/j.compbiomed.2021.104915
PMCID: PMC8492016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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